Throughout the website and blogs page there is a host of information to be found. This is where you can find links to reference material supporting the many articles and statements made. There is a certain amount of overlap with the reference section in the PDF papers and articles available on the download page. This page is fluid and constantly evolving. Do visit often.
Since copyright subsists in many of these works, simple links to where they can be read are provided. In some cases the reviewed papers are in abstract form and others are full text papers. Many of the publishing platforms require registration in one form or another to see full script papers.
Many of these papers are peer reviewed work and represent the accepted position in the scientific world. They are published by respected journals and most often contain a full author informational section.
This is some of the data available today in support of the more widespread use of hyperbaric oxygen therapy. Research is ongoing as well. Check back often for new additions to the list of well researched and meticulously conducted studies.
We are often challenged to cite data sets. These are those data.
Gas Laws.
Many of the articles refer to the “gas laws” and how they relate to HBOT. These are irrefutable scientific laws established in some cases, hundreds of years ago.The Wiki link lists all relevant gas laws involved with working with pressure and gasses.
https://en.wikipedia.org/wiki/Gas_laws
Adiabatic Process
In some of the articles involving physics, and specifically the heating and cooling of chambers, reference is made to adiabatic heating and cooling or just adiabatic process. the Wiki link supports.
https://en.wikipedia.org/wiki/Adiabatic_process
Hyperbaric Oxygen Therapy Increases Insulin Sensitivity In Overweight Men With and Without Type 2 Diabetes
Pursuant to the in-house paper on diabetes and insulin sensitivity.
https://www.ncbi.nlm.nih.gov/pubmed/25964036
A Sign of Rapid Body Weight Loss Under Hyperbaric Oxygen Treatment Was Observed in Mice With Non-Alcoholic Fatty Liver Disease
Also pursuant to the paper on diabetes.
http://archive.rubicon-foundation.org/xmlui/handle/123456789/9111
Hyperbaric Oxygen Prevents Early Death Caused by Experimental Cerebral Malaria
Pursuant to the chapter in the overview paper available for download.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518956/
Hyperbaric Oxygen Effects on Sports Injuries
Further to the articles and overview chapters on how hyperbaric oxygen helps in recovery from sports injuries.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382683/
The Effect of Hyperbaric Oxygen on Severe Anemia
The article and chapter in this is well supported.
https://www.ncbi.nlm.nih.gov/pubmed/23045922
Time Is Brain – Quantified
This paper is not specifically one on HBOT but adds data to the time sensitivity issue discussed when brain injury is concerned.
https://www.ahajournals.org/doi/full/10.1161/01.STR.0000196957.55928.ab
Tissue Granulation
The Wiki link describes the process involved in tissue regeneration and granulation following injury.
https://en.wikipedia.org/wiki/Granulation_tissue
Vascular Endothelial Growth Factor (VEGF)
The underlying basis on which HBOT works for healing is based on the up-regulation of the VEGF and this Wiki link explains what that is.
https://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor
Bone Healing
The description of the bone healing process relevant to the articles on would healing and sports injuries.
https://en.wikipedia.org/wiki/Bone_healing
Hyperbaric Oxygen Therapy and Cancer – A Review
In 2012 a major review of literature took place changing the mainstream view on cancer and HBOT.
https://link.springer.com/article/10.1007/s11523-012-0233-x
Not Just Full of Hot Air: Hyperbaric Oxygen Therapy Increases Survival in Cases of Necrotizing Soft Tissue Infections
An important one in support of wound healing and evidence of anti bacterial efficacy of HBOT.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696431/
Stem Cell Mobilization by Hyperbaric Oxygen
An integral part of the healing process and one of it’s pillars is the availability of stem cells.
https://www.ncbi.nlm.nih.gov/pubmed/16299259
Time Perception Mechanisms at Central Nervous System
Nothing to do with HBOT this one, just very interesting.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830363/
Amber Provides New insights Into The Evolution of Earth’s Atmosphere: Low Oxygen Levels For Dinosaurs
Relevant information as it pertains to the opening paragraphs of the overview document. Giving the counter argument to gigantism and oxygen.
https://www.sciencedaily.com/releases/2013/11/131118081043.htm
Hyperbaric History
There are an infinite number of similar articles online. This is just one of a great many.
https://guides.mclibrary.duke.edu/hyperbaric/history
Pulmonary Gas Exchange
The basis on which we are able to breathe and the basis on which oxygen enters the blood stream via the lungs. A pressure driven phenomenon.
https://www.atsjournals.org/doi/full/10.1164/ajrccm.157.4.nhlbi-4
High Altitude Hypoxia: An Intricate Interplay of Oxygen Responsive Macroevents and Micromolecules
Details the mechanism of hypoxia at elevated altitude. The refers to the effect of hyper oxygenation under increased pressure.
https://www.ncbi.nlm.nih.gov/pubmed/14619980
Medicine and mechanisms in altitude sickness. Recommendations
More information on altitude induced hypoxia.
https://www.ncbi.nlm.nih.gov/pubmed/8570999
Anatomy and Physiology
General anatomy and Physiology.
Cover
Deep Hydrogen Diving : Hydra 10 – A 701 MSW Record Dive
The cited article on the deep Hydreliox dive conducted by Comex.
http://archive.rubicon-foundation.org/xmlui/handle/123456789/8144
Oxygen Toxicity and Special Operations Forces Diving: Hidden and Dangerous
One of the contributing sources for the article series on oxygen toxicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524741/
Model of CNS O2 Toxicity in Complex Dives With Varied Metabolic Rates and Inspired CO2 Levels
Another contributing source to the oxygen toxicity discussions.
https://www.ncbi.nlm.nih.gov/pubmed/12793535
The Space-Flight Environment: The International Space Station and Beyond
A number of articles draw parallels between hyperbaric technology and that used in space exploration. This is among the sources of information.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691437/
Diabetic Retinopathy Analysis
The Articles on Macular Degeneration and Diabetes discuss various aspects of retinopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1138264/
The Applications of Hyperbaric Oxygen Therapy in Emergency Medicine
As discussed in the anaemia article as well as others.
https://www.sciencedirect.com/science/article/abs/pii/073567579290185Z
Regulation of Tissue Oxygenation
Tissue oxygenation is the underlying mechanism of the repair and rebuild process responsible for healing.
https://www.ncbi.nlm.nih.gov/books/NBK54104/
Is the VO2max That We Measure Really Maximal?
Pursuant to the discussions on sports performance and weight loss and the rationale behind the position that HBOT increases metabolic function as pressure increases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733001/
Validity of Criteria For Establishing Maximal O2 Uptake During Ramp Exercise Tests
Questioning the validity of tests like the Chester Step test as an indication of VO2 maximal uptake or level of fitness.
https://www.ncbi.nlm.nih.gov/pubmed/17968581/
Hyperbaric Oxygen Therapy – The New England Journal of Medicine
An overview from the folks at NEJM.
https://www.nejm.org/doi/full/10.1056/nejm199606203342506
Hyperbaric Oxygen Therapy Mediates Increased Nitric Oxide Production Associated With Wound Healing: A Preliminary Study
Nitric oxide being the basis of wound healing and one of the key mechanism in triggering healing following injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756815/
Hyperbaric Oxygen in The Treatment of Postoperative Infections in Paediatric Patients With Neuromuscular Spine Deformity
Similar considerations apply and anti bacterial properties are common to other post operative infections also.
https://www.ncbi.nlm.nih.gov/m/pubmed/21523458/
Driving CAR T-Cells Forward
Not an HBOT one but a very interesting subject is CAR – T cells in cancer therapy.
https://www.ncbi.nlm.nih.gov/pubmed/27000958
Oxygen Chamber Can Boost Brain Repair
Great Study from Prof Shai Efrati at the Tel Aviv University Israel.
https://english.tau.ac.il/news/oxygen_chamber_can_boost_brain_repair
Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial
Also from Prof Shai, a study into diminishing the effects of fibromyalgia and chronic pain syndrome.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012
Human Hippocampal Neurogenesis Persists Throughout Aging
Recent research concluding the continued growth of brain cells throughout ones life.
https://www.ncbi.nlm.nih.gov/pubmed/29625071
Effects of Gut Microbes on Nutrient Absorption and Energy Regulation
Not directly HBOT but related to it as current research is ongoing in the relationship between HBOT and the human microbiome. (Efrati Et Al)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601187/
Effects of Acute Hypoxia on Heart Rate Variability, Sample Entropy and Cardio-respiratory Phase Synchronization
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059097/
Adjunctive Hyperbaric Oxygen in Diabetic Foot Ulcers – A Randomised, Prospective, Double-Blind Study
A particularly important conclusion in support of HBOT for foot ulcers and reduced mortality.
http://archive.rubicon-foundation.org/xmlui/handle/123456789/1604
Hyperbaric Oxygen Therapy: Side Effects Defined and Quantified
Also very important to note are potential side effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467109/
Hyperbaric Oxygen: It’s Mechanisms and Efficacy
Another overview from an independent, peer reviewed source.
https://www.ncbi.nlm.nih.gov/pubmed/21200283/
Repetitive Long-Term Hyperbaric Oxygen Treatment (HBOT) Administered after Experimental Traumatic Brain Injury in Rats Induces Significant Remyelination and a Recovery of Sensorimotor Function
Pertaining to de-mylination in the brain characteristic in cases of TBI as well as potential benefit for multiple sclerosis. Efficacy in re-mylination is supported.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029808/
Effects of Hyperbaric Oxygen on Metabolic Capacity of the Skeletal Muscle in Type 2 Diabetic Rats with Obesity
A good one concluding that hyperbaric oxygen enhances glucose and lipid metabolism in the skeletal muscle, indicating that hyperbaric oxygen can prevent elevation of glucose and adipocyte hypertrophy in diabetic rats with obesity.
https://www.hindawi.com/journals/tswj/2012/637978/
Cell Structure
https://training.seer.cancer.gov/anatomy/cells_tissues_membranes/cells/structure.html
Brief description of cell structure.
Cell Function
And also one on cell function.
https://training.seer.cancer.gov/anatomy/cells_tissues_membranes/cells/function.html
Hyperbaric Oxygen Can Induce Angiogenesis and Recover Erectile Function
Another research project from Prof Shai Efrati et al. The reversal of erectile dysfunction.
https://www.nature.com/articles/s41443-018-0023-9
Carbon Dioxide Poisoning: A Literature Review of an Often Forgotten Cause of Intoxication in the Emergency Department
Intoxication of any kind can be helped by HBOT. The added oxygen flushes the toxin in the case of gas poisoning and metabolises the toxin in other cases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380556/
Carbon Dioxide Poisoning
More information on carbon dioxide poisoning which can be helped with HBOT. Interesting reading on a dangerous occurrence that must be considered in HBOT.
https://www.ncbi.nlm.nih.gov/pubmed/16499405
Hyperbaric Oxygen Treatment Suppresses Withdrawal Signs in Morphine-Dependent Mice
In a world with increasing opiate addiction a novel approach and preliminary trials indicate that withdrawal can be halved using HBOT.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018463/
Hyperbaric Oxygen Toxicity in Brain: A Case of Hyperoxia Induced Hypoglycemic Brain Syndrome
The cited paper from the discussion on oxygen toxicity. This very recent (late 2019) paper shows that toxicity events in the brain is a hypoglycemic event. It also supports the evidence that HBOT stimulates greater glucose metabolism. which is good for diabetics.
https://www.sciencedirect.com/science/article/pii/S0306987719307376?dgcid=raven_sd_aip_email
Undersea and Hyperbaric medical Society – Acute Thermal Burns release.
Further reading on thermal burns supported and advocated by the UHMS
https://www.uhms.org/13-acute-thermal-burn-injury.html
Longevity: Why There’s More Depression. Anxiety and Suicide at High Altitude.
Discussed in more detail in the post on depression this is one source article on the subject.
Thriving at Altitude, Part 3: Why There’s More Depression, Anxiety and Suicide at High Altitude
The second article source to the depression discussion.
Hypoxia by Edward Van Liere and J Clifford Stickney
The original source study refereed to in the articles on depression at altitude.
Hyperbaric Oxygenation in the Treatment of Patients With Drug Addiction, Narcotic Addiction and Alcoholism in the Post-Intoxication and Abstinence Period
The abstract cited in the article discussing detox and drug addiction withdrawal.
https://www.ncbi.nlm.nih.gov/pubmed/7653862
Hyperbaric Oxygen Treatment Suppresses Withdrawal Signs in Morphine-Dependent Mice
Another source cited in the addiction article.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018463/
Hyperbaric Oxygenation in Treatment of Alcohol Dependence Syndrome
The third resource cited in the addiction discussion published 2016.
https://clinicaltrials.gov/ct2/show/NCT03470168
Alcohol-Induced Brain Damage Continues After Alcohol is Stopped
Cited in the discussion on addiction and withdrawal this is a very recent study with remarkable findings showing that brain damage continues for up to 6 weeks after cessation of alcohol.
https://www.sciencedaily.com/releases/2019/04/190403113922.htm
Hyperbaric Environment: Oxygen and Cellular Damage versus Protection Introduction and History of Hyperbaric Oxygen Therapy
As also shared on the blog entitled: Spreading The Word of Others
Hyperbaric Oxygen Therapy: Exploring the Clinical Evidence
An easy reading overview.
Comprehensive Review of Hyperbaric Oxygen Therapy
Reference material from the Social media post.
Human Microvascular Endothelial Cells Treated With Hyperbaric Oxygen Become Resistant To Lethal Oxidation And have Increased Expression Of Cytoprotective Genes
The main reference in the articles on genetics.
Early and Late Effects of Hyperbaric Oxygen Treatment on Oxidative Stress Parameters in Diabetic Patients
More information discounting oxygen toxicity, specifically targeting diabetic patients.
Hyperbaric Oxygen Therapy and the Eye
A very comprehensive paper on HBOT & opthalmology.
https://www.academia.edu/27654545/Hyperbaric_Oxygen_Therapy_and_the_Eye?email_work_card=title
Idiopathic Sudden Sensorineural Hearing Loss (New! approved on October 8, 2011 by the UHMS Board of Directors)
Pursuant to the article on HBOT and the ears.
Hyperbaric Oxygen Therapy in Tinnitus With Normal Hearing in Association With Combined Treatment.
Also mentioned in the article on HBOT and the ears.
https://www.ncbi.nlm.nih.gov/pubmed/27416687
Hyperbaric Oxygen Therapy Activates Hypoxia-Inducible Factor 1 (HIF-1), Which Contributes to Improved Wound Healing in Diabetic Mice
More supporting evidence of HBOT efficacy in the upregulation of HIF 1alpha and its role in wound healing.
IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers
Hyperbaric Contra Indications
https://www.ncbi.nlm.nih.gov/books/NBK557661/
Hyperbaric Oxygen Therapy: Side Effects Defined and Quantified
Click to access HBOTSideEffects_AdvWoundCare_2017.pdf
Additional Wiki Links to descriptions and definitions of various related Terminology and Conditions Used in Various Papers and Articles
Glycated hemoglobin – Wikipedia
Adenosine triphosphate – Wikipedia (ATP)
©Copyright Cumbria Hyperbaric 2019
cumbria-hyperbaric.org 